|HitPredict is a resource of high confidence protein-protein interactions. Interactions can be searched and downloaded with their predicted confidence level.|
Protein-protein interactions from IntAct, BIOGRID and HPRD are combined, annotated and assigned a reliability score in order to identify a high confidence subset.
The reliability score is calculated as the Likelihood Ratio using naive Bayesian networks combining sequence, structure and functional annotations of the interacting proteins.
HitPredict has 239584 protein-protein interactions across 9 species, 168458 of which are predicted to be of high confidence.
Ashwini Patil, Kenta Nakai and Haruki Nakamura; HitPredict: a database of quality-assessed protein-protein interactions in nine species, Nucl. Acids Res. 2011 Database Issue:D744-9
Ashwini Patil and Haruki Nakamura; Filtering high-throughput protein-protein interaction data using a combination of genomic features, BMC Bioinformatics, 2005, 6:100